Andrew Macpherson is Professor of Medicine and Director of Gastroenterology at the University Hospital of Bern in Switzerland. His medical training was at Cambridge, where he also did his Ph.D. in Biochemistry. An interest in host-microbial mutualism stemmed from studies in inflammatory bowel disease during his Training Fellowship at the MRC Clinical Research Centre. His lab has been focused on the induction and function of mucosal IgA responses and how mucosal and systemic immune responses against commensal intestinal microbes are compartmentalised. His group have refined the methodology for axenic and gnotobiotic animal experimentation, to allow efficient strain combination experiments at germ free or defined colonisation status. They have also recently developed a system of reversible colonisation of germ free animals so mucosal immunity can primed with live commensal bacteria which do not persist in vivo, thus uncoupling mucosal immune priming and colonisation.
« Go Back